The goals of treating hyperthyroidism are to relieve signs and symptoms, reduce thyroid hormone production to normal levels and achieve biochemical euthyroidism, and prevent long-term adverse sequelae.
Propylthiouracil (proe-pill-thye-oh-yoor-a-sill) and Methimazole are the best initial therapies for Hyperthyroidism. They are used to lower the level of thyroid hormone. They do not block the target organ effect. PTU is safe during pregnancy.
Propylthiouracil inhibit the peroxidase enzyme. This blocks the oxidation of iodine, inhibits the incorporation of iodine onto tyrosine, and stops the coupling of these compounds into T3 and T4. Hence, these medications block three essential steps in the formation of thyroid hormone. It’s basically inhibits iodination step of thyroid
The most important adverse effect of these compounds is neutropenia. Both lower granulocyte levels by inhibiting the bone marrow. Purpuric skin lesions may also occur.